Pharmaceutical Packaging Pouches for API & Drug Packaging

What are cleanrooms?

A cleanroom is generally a clean and compact place for testing, experiments, etc. These rooms are seen in hospitals, laboratories, and other pharma industries. Such rooms tend to be free from moisture and other contaminants that can harm the products inside the cleanroom. 

Cleanrooms typically have high-efficiency particulate air (HEPA) filters and strict personnel attire and behaviour protocols. They are commonly used in pharmaceuticals, electronics, and medical devices to ensure product quality and safety. 

However, regarding the safety of cleanroom products, several solutions are available in the market today, like the LDPE bags, also known as "Cleanroom bags". Let's read further about LDPE bags in detail through this blog and know how they help preserve the quality of cleanroom products. 

Why LDPE bags for cleanrooms?

Low-density polyethylene (LDPE) bags are widely used in cleanrooms to maintain the cleanliness and sterility of the environment. Cleanrooms are critical environments where products are manufactured, tested, and assembled in a controlled setting. These environments require strict standards of cleanliness to ensure that the products produced are of the highest quality and contaminate-free.

LDPE bags for cleanrooms are made from a type of plastic that is lightweight, durable, and resistant to moisture, chemicals, and other contaminants. They are essential to cleanroom operations, as they provide a reliable barrier against airborne particles and microorganisms that can compromise the environment's integrity.

Additionally, LDPE bags have high moisture barrier and ultra-clean high-barrier properties, which initially keep the products free from moisture and contaminates, making them suitable for general cleanroom applications.

How are LDPE bags beneficial for cleanrooms?

One of the primary benefits of using LDPE bags for cleanrooms is their ability to prevent contamination. These bags are manufactured in a controlled environment and are designed to meet strict quality standards. They are free from particles, fibres, and other contaminants that can be introduced into the cleanroom environment. Additionally, LDPE bags for cleanrooms are available in various sizes and configurations, making them suitable for various applications, including storing and transporting sensitive components and materials.

Another benefit of using LDPE bags in cleanrooms is their ease of use. These lightweight and flexible bags make them easy to handle and transport. They can be easily sealed with heat or adhesive closures, ensuring the contents remain secure and protected from contamination. Additionally, LDPE bags are transparent, allowing for easy identification of the contents without the need to open the bag.

When selecting LDPE bags for cleanroom use, choosing bags that meet the necessary quality standards is essential. Additionally, LDPE bags are designed for specific applications, such as those that are antistatic and UV resistant, to ensure that they meet the specific needs of your cleanroom operation.

Thus, LDPE bags are an essential component of cleanroom operations. They provide a reliable barrier against contamination, are easy to use, and are available in various sizes and configurations. When selecting LDPE bags for cleanroom use, it is essential to choose bags that meet the necessary quality standards and are designed for the specific needs of your operation. By using LDPE bags in your cleanroom, you can help ensure that your products get better safety and retain quality.

Features of LDPE bags:

• Linear Low Density
• Fractional Melt Low Density
• UVI
• Antistatic
• Flame retardants and Antiblock Additives are used in our LDPE bags.
• In-house testing is done for - Full physical testing capabilities, including FT-IR, DSC, Tensile, seal, and burst strength.
• Compliances: 21 CFR 178.3130

We accept your inquiry by email at sales@ldpebag.com and by phone at +91 9879203377, samples are provided according to your needs and specification.

Low-density polyethene (LDPE) bags are popular for API packaging (active pharmaceutical ingredients) and bulk drug packaging. They are reliable and provide high protection for the product inside.

LDPE bags are made from a special blend of polyethene and other materials, making them resistant to water and chemical damage. This makes them an ideal choice for API packaging, which is often moisture-sensitive and requires an airtight seal. The material is also lightweight and flexible, making it easy to transport and store.

The bags are strong, with high tear resistance, as they help to protect the product from damage in transit and during storage. Thus, low-density polyethene (LDPE) bags are an excellent choice for Active packaging in pharmaceuticals, as they offer superior protection from light-causing contamination and moisture, rising humidity, and other environmental factors.

Additionally, they are highly customizable and can be sealed securely with various methods. Therefore, they are also environmental-friendly, as they can be recycled. With these benefits in mind, it is easy to see why low-density polyethene bags are an ideal choice for healthcare products and the industry.

Features

• Linear low-density
• Fractional Melt low-density
• UVI
• Antistatic
• Flame retardants and Antiblock Additives are used in our LDPE bags
• In-house testing is done for -Full physical testing capabilities, including FT-IR, DSC, Tensile, seal and burst strength.
• Compliances such as ISO 9002, USFDA Approved, EU compliance, 21 CFR 178.3130.

However, as potential distributors of LDPE bags, we also help our customers customize the bags with printed company logos or other information to help promote their products. Additionally, they are available in various sizes to suit different applications. This makes them a great choice for API packaging, as they can be tailored to meet the product's specific needs.

Overall, LDPE bags are a popular choice for active pharmaceutical packaging due to their versatility, durability, and ability to protect against moisture, oxygen, light, and other environmental factors that can affect the quality of pharmaceutical products.

HDPE and LDPE are derived from polyethene (PE), the most popular plastic used worldwide. These two materials belong to the polyethene family of thermoplastic, extracted from petroleum through the polymerization process. 

Polyethene is generally a mixture of organic compounds and is categorized into different groups based on density and branching. It has a simple molecular structure and is most commonly found in everything, including toys, shopping bags, water bottles, etc. 

The key difference between LDPE and HDPE is the polymer molecule's density or alignment. The difference between LDPE and HDPE is that the HDPE polymers are straight and closely packed, whereas the LDPE polymers are not closely packed and have many branches. 

Another significant difference between these materials is their overall durability and rigidity, as the LDPE bags are more flexible than HDPE bags. This is due to the crystalline structure between these two bags. However, LDPE is known to have a much lower melting point and is most likely to get cracked under high pressure and stress. 

The bags also need to be recycled in different methods, which is why HDPE bags are more widely recycled than LDPE bags. In addition, the HDPE recycling process is more straightforward than recycling LDPE.

The primary attributes of LDPE and HDPE:

LDPE: The transparent plastic bags are flexible, have waterproofing capacity and have incredible chemical resistance. It is utilized in the making of a wide range of products. The most common applications are grocery bags, plastic wrap & films, and injection moulded components.

HDPE: the popular plastic material is known for exhibiting a high impact on strength and durability. It is available in many variations like transparent & opaque. 

LDPE Bags:

LDPE bags (low-density polyethene bags) are soft, flexible and lightweight plastic materials. The bags are less dense because of the increased space between the branches during the polymerization process. This makes it immensely flexible than HDPE bags. They also have better clarity than dense polyethene materials. LDPE bags are easy to tear, which is an advantage while opening the packages. They work excellent with chemicals and are easy to fabricate. 

LDPE bags are produced by either a stirred autoclave or a tubular reactor. It is generally a manufacturing process involving ethylene gas polymerization and gas separation compression. 

LDPE bag's density range is 0.91-0.94g/cm³. The branched polymer is synthesized from ethylene by a catalytic procedure. More branching makes the molecules packing irregular, and intermolecular bonds become weaker than in HDPE bags. As a result, these bags are flexible but can't tolerate higher temperatures.

Advantages:

• Low cost
• Resistant to acids and bases
• Accessible to process and mould
• Good electrical insulation
• Waterproof property

Applications:

• Food items
• Grocery and produce bags
• Corrosion-resistant work surfaces
• Packaging for computer hardware

LDPE is majorly used for Pharmaceutical and API Packaging

It is said that LDPE bags are ideal for pharmaceutical and API packing, which meets the needs at an affordable cost. The bags are essentially long-chain polymers made from ethylene gas through polymerization. This process is performed under high pressure. Therefore, because of this reason, the bags can withstand high ambient temperatures and are highly flexible. In addition, the LDPE bags provide a moisture-free environment and extend the stored products' shelf-life. Such properties are necessary for the pharmaceutical industry. 

The pharmaceutical industry uses these bags for storing and packaging medicines and bulk drugs. This also maintains the consistency of the delivered product and enables the production of high-quality finished goods. E.g., tablets and capsules. 

API:

API (Active Pharmaceutical Ingredients). It is crucial to maintain the effectiveness and quality of the API for producing tablets, capsules and several other drugs. The temperature changes can affect the API products. Because of this reason, the products are packed in pharma-grade bags to preserve their quality and effectiveness from getting damaged. These bags act as a protective barrier to uphold the properties of the API products. 

API LDPE bags are also used with pharma-grade bags, especially while transporting products in powder, beads, or other forms. It generally keeps the APIs away from chemical and biological reactions. These bags can also be provided for various thickness-based requirements, particularly for the transported product. 

Pharma-grade bags:

The pharma-grade bags are made of laminated material, commonly used for pharma product packaging. However, as we know, pharma products are susceptible, and delivering these sensitive products is more challenging for healthcare manufacturers. 

To sustain the efficiency, quality and performance of the medicines, pharma-grade bags are a practical solution for eliminating the risk of leakage and moisture effects and providing the safest delivery of the pharma products. These bags are moisture-free, odourless and even non-toxic. They also have an additional advantage of extending the shelf life of the products. 

Thus, the pharma-grade bags are perfect for protecting bulk tablets, drugs and medical powders, especially from moisture and humidity. In addition, these bags are manufactured without adding additives or chemicals, so there is less chance of adverse effects on the tablets, capsules and drugs packed in pharma-grade bags. 

Pharma-grade bags are available in different sizes and shapes, depending on the product's packaging. Bags are also considered one of the economical ways to protect medicines and drugs from getting affected by moisture and humidity by maintaining the clarity and quality of the film. 

HDPE Bags:

HDPE (high-density polyethene bags) are durable, versatile, low-cost and chemical-resistant plastics. These bags are denser than LDPE bags because of the branching structure of the polymer chain. This makes them more durable and resistant to tear, but these are not much flexible as LDPE bags. Denser and more durable, they are most commonly used for heavy-duty packaging. HDPE bags are also excellent for fabricated water and chemical tanks.

The HDPE bags are generally produced by heating the petroleum at high temperatures using slurry polymerization or phase polymerization. The production process begins with the polymerization solution of ethylene monomers after operation and drying. 

It is manufactured in low temperatures ranging from 70°C to 300°C, rather than LDPE. HDPE is mainly obtained through the catalytic cracking of crude oil into gasoline or natural gases like methane, ethane, etc.

Advantages:

• Low cost
• High tensile strength
• Able to resist low temperature
• Relatively strong and stiff
• Waterproof property
• Good electrical insulation

Applications:

They are commonly used for packaging:

• Construction materials like cement or sand
• Bulk dry goods like rice or grain
• Auto parts and tools
• Chemical containers
• Chemical-resistant piping
• Fuel tanks 
• Food storage containers

Few similarities between both HDPE and LDPE bags:

• Low material weight
• High impact strength
• High recyclability
• Cost-effectiveness
• Low cost of manufacturing
• Resistance to chemicals 

Several similar applications like:

• Packaging
• Pipes & Fittings
• Electrical
• Automotive
• Hydraulics & pneumatics

LDPE bags are the most frequently used product in the market. It is also said to be Low-Density poly ethane bags. These bags are made from petroleum, which initially goes through many high-pressure free radical polymerization processes. There is one more reason behind its popularity that is it has excellent recycling capability. These bags are extensively used in the pharma packaging industry. When kept at normal room temperatures, it shows its least reactive activities. It can easily withstand temperatures up to 80o centigrade and shows high resistance against acids, bases, and alcohols. Its high resistance against vegetable oils, mineral oils, and various oxidizing agents has highly increased its demand in the packaging and medical industries. It is almost used in every medical agency for the packaging of medicines. When packed in these LPED bags, the medicines show their least reactive actions until the bag is opened.

As LDPE can be molded easily, it is also used molded and used in various laboratory equipment as well. In laboratories, it is used to store highly sensitive powdered chemicals. The reactions mostly occur when the products are exposed to the environment. So, chemical powders are packed in these LDPE bags when transporting medicines. These LDPE bags are also good from an environmental perspective as they recycle easily without polluting the environment. Although these LDPE bags are light-weighted and flexible, they can carry more than 50 times their weight.

Suppose the bags are manufactured by a good company and meet the requirements and standards set by the national and international governments. In that case, it can be used for various laboratory purposes as well. The size, color, and even thickness of bags can be customized easily as per the requirements. Many times, LDPE is mixed with other materials as well to overcome some of its drawbacks and to make it stronger. The bags made from LDPE tend to be more slippery, so sometimes, some additives are mixed to make them less slippery. These bags also tend to charge up on their own, so it can be quite risky when using any electronic item. That is why Anti-static additives are mixed to keep it static-free.